ncRNA name | hsa-miR-17 |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB cell lines Y79 and WERI-RB1 |
Methods | qPCR, flow cytometry, MTT assay, cell cytotoxicity assay |
Expression pattern | up-regulated |
Functional description | We focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the maturation of miR-17, miR-18a, and miR-19b (P<0.05) for targeting RB. Cellular changes upon transfecting the pri-apt led to S-phase arrest in WERI-RB1 cells and onset of apoptosis in both Y79 and WERI-RB1 cell lines. |
PubMed ID | 25513843 |
Year | 2015 |
Title | Blocking the maturation of OncomiRNAs using pri-miRNA-17∼92 aptamer in retinoblastoma. |
Drug-related ncRNA | NO |
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